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RABO37.29.31.138 t.n.v. Stichting Gezondheid Actueel in Terneuzen.
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Alle abstracten gepresenteerd tijdens de SGO 2019 (50th Annual Meeting of the Society of Gynecologic Oncology) staan in deze PDF. waaronder ook onderstaande studie.
Wanneer vrouwen met een positief uitstrijkje dat aantoont dat zij draagster zijn van het HPV virus (humaan papillomavirus) dagelijks gedurende 6 maanden een AHCC extract nemen dan verdwijnt binnen 6 maanden de HPV infectie bij 63,4 procent van de draagsters tegenover bij 10,5 procent van de vrouwen die een placebo kregen. Dit blijkt uit een gerandomiseerde placebo gecontroleerde studie bij totaal 50 vrouwen met een aantoonbare HPV infectie.
Dr. Smith en haar collega's wilden onderzoeken wat de effecten zouden zijn op het dagelijks gebruik van een AHCC supplement (3 gram) oraal in te nemen. Om op die manier HPV-infecties te bestrijden bij vrouwen van wie hun PAP-uitstrijkjes positief waren en de aanwezigheid van het HPV virus hadden aangetoond. (Het HPV virus is heel vaak oorzaak van Baarmoederhalskan*er en ook blijkt meer en meer dat het HPV virus vaak ook de oorzaak van Mond- en Keelkanker is)
Een voorlopige analsye bevestigt dat bij 63,4 procent van de deelnemende vrouwen die het AHCC supplement hadden gekregen het HPV virus was verdwenen. Bij slechts 2 vrouwen (10,5 procent) uit de placebogroep was het HPV virus verdwenen op 1-jaars meting.
Dr. Smith zegt, “Supplementation with active hexose-correlated compound was well tolerated, with minimal potential for drug/supplement interactions.” Dus AHCC is een effectief en duurzaam voedingssupplement zonder extra bijwerkingen. (Een AHCC extract zou dus wellicht een goed alternatief voor vaccinatie kunnen zijn?)
“These phase II results are a major milestone in our research. We now plan to optimize and individualize treatment. The duration of supplementation with the compound after the first negative result also needs further evaluation.”
“Our hope is that, ultimately, the supplement will be used to eradicate HPV in both women and men.”
Judith A. Smith1,2*, 
Lata Mathew1, 
Anjali Gaikwad1, Barbara Rech3, Maryam N. Burney1, Jonathan P. Faro4, Joseph A. Lucci III1,2, Yu Bai5, Randall J. Olsen6 and 
Teresa T. Byrd1
- 1Department of Obstetrics, Gynecology and Reproductive Sciences, UTHealth McGovern Medical School, Houston, TX, United States
- 2Department of Pharmacy, Memorial Hermann Cancer Center, Houston, TX, United States
- 3UT Physicians Women's Center, Houston, TX, United States
- 4Specialists in Obstetrics & Gynecology, Houston, TX, United States
- 5Department of Pathology, UTHealth McGovern Medical School, Houston, TX, United States
- 6Department of Molecular Pathology, Institute for Academic Medicine, Houston Methodist Research Institute, Houston, TX, United States
Objective: There is currently no effective medicine or supplement for clearance of high risk- human papillomavirus (HR-HPV) infections. We have taken a systematic approach evaluating the potential use of AHCC supplementation to support clearance of HR-HPV infections. The primary objective of this research was to evaluate AHCC supplementation to modulation of the host immune system to clear HR-HPV infections from bench to bedside.
Methods: Cervical cancer cells, CaSki (HPV16+), HeLa(HPV18+), SiHa(HPV16/18+), and C-33A(HPV−), were treated in vitro with AHCC 0.42 mg/mL daily x7 days then observed x7 days with daily sample collection. A confirmatory study in cervical cancer mouse models, SiHa(HPV16/18+) and C-33A(HPV−), was conducted: mice were divided into three groups per cell line then dosed with AHCC 50 mg/kg/d (N = 10), or vehicle alone (N = 10), or no supplementation (N = 10) for a total of 90 days followed by 30 days of observation. Tumors were measured 3x/week and blood samples collected bi-weekly to evaluate interferon (IFN) alpha(α), beta(β), and gamma(γ) and immunoglobulin G(IgG) by immunoassays. Tumors were evaluated for HR-HPV expression by PCR. Two pilot studies of 10 patients each were conducted in women with confirmed persistent HR-HPV+ infections. The 1st study evaluated AHCC 3g from 5 weeks up to 6 months and 2nd study evaluated AHCC 1g < 8 months. HR-HPV DNA status and the immune panel were monitored at each visit.
Results: HR-HPV clearance was observed in vitro and confirmed in the animal studies as a durable response. Four of six (66.7%) patients had confirmed HR-HPV clearance after 3–6 months of AHCC 3g. Similarly, 4 of 9 (44%) patients had confirmed HR-HPV clearance after 7 months of AHCC 1g. Suppression of IFNβ <25 pg/mL was observed in those clearing the HR-HPV infection.
Conclusion: Pre-clinical in vitro and in vivo studies demonstrated durable clearance of HR-HPV infections. The preliminary data from the two pilot studies suggested that AHCC supplementation supports the host immune system for successful clearance of HR-HPV infections. A confirmatory phase II randomized, double-blinded, placebo-controlled study is ongoing.
Author Contributions
JS contributed to conceptualization, data curation, formal analysis, funding acquisition, investigation, methodology, project administration, supervision, writing—original draft and editing. LM and AG contributed to data curation, investigation, formal analysis, methodology, validation, writing—original draft, review and editing. BR and MB contributed to data curation, investigation, writing—review and editing. JF contributed to methodology, investigation, writing—review and editing. JL and TB contributed to investigation, writing—review and editing. YB and RO contributed to methodology, supervision, writing—review and editing.
Funding
This research was partially supported by an unrestricted research grant from Amino Up Chemical Company; Larry C. Gilstrap M.D. Center for Perinatal and Women's Health Research; and WHIM Research Program philanthropic funds; NIH 1R03CA212935.
Conflict of Interest Statement
JS has been principal investigator on unrestricted research grants from Amino Up Chemical Company to the institution for preliminary preclinical studies.
The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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